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Year Number of Results
1999 2
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2003 6
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2008 13
2009 19
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2013 24
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368 results

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Page 1
Coactivator-associated arginine methyltransferase 1: A versatile player in cell differentiation and development.
Ma Z, Lyu X, Qin N, Liu H, Zhang M, Lai Y, Dong B, Lu P. Ma Z, et al. Genes Dis. 2022 Jun 3;10(6):2383-2392. doi: 10.1016/j.gendis.2022.05.021. eCollection 2023 Nov. Genes Dis. 2022. PMID: 37554200 Free PMC article. Review.
Protein arginine methylation is a common post-translational modification involved in the regulation of various cellular functions. Coactivator-associated arginine methyltransferase 1 (CARM1) is a protein arginine methyltransferase that as …
Protein arginine methylation is a common post-translational modification involved in the regulation of various cellular functions. Coacti …
Development of Potent and Selective Coactivator-Associated Arginine Methyltransferase 1 (CARM1) Degraders.
Xie H, Bacabac MS, Ma M, Kim EJ, Wang Y, Wu W, Li L, Xu W, Tang W. Xie H, et al. J Med Chem. 2023 Sep 28;66(18):13028-13042. doi: 10.1021/acs.jmedchem.3c00982. Epub 2023 Sep 13. J Med Chem. 2023. PMID: 37703322
Potent small-molecule inhibitors for CARM1 have been developed, but the cellular efficacy of the CARM1 inhibitors is limited. ...Thus, CARM1 PROTACs can be used to interrogate CARM1's cellular functions and potentially be developed as therapeutic agent …
Potent small-molecule inhibitors for CARM1 have been developed, but the cellular efficacy of the CARM1 inhibitors is limited. …
CARM1 arginine methyltransferase as a therapeutic target for cancer.
Santos M, Hwang JW, Bedford MT. Santos M, et al. J Biol Chem. 2023 Sep;299(9):105124. doi: 10.1016/j.jbc.2023.105124. Epub 2023 Aug 1. J Biol Chem. 2023. PMID: 37536629 Free PMC article. Review.
Coactivator-associated arginine methyltransferase 1 (CARM1) is an arginine methyltransferase that posttranslationally modifies proteins that regulate multiple levels of RNA production and processing. ...This review is meant to kindle an i …
Coactivator-associated arginine methyltransferase 1 (CARM1) is an arginine methyltransferase that …
Coactivator-associated arginine methyltransferase 1 controls oligodendrocyte differentiation in the corpus callosum during early brain development.
Ishino Y, Shimizu S, Tohyama M, Miyata S. Ishino Y, et al. Dev Neurobiol. 2022 Apr;82(3):245-260. doi: 10.1002/dneu.22871. Epub 2022 Mar 11. Dev Neurobiol. 2022. PMID: 35220691
Carm1 regulates cell proliferation of a neuronal cell line and is reportedly expressed in the mammalian brain. ...Thus, we propose that Carm1 is an essential molecule for the development of OPCs and OLs during brain development....
Carm1 regulates cell proliferation of a neuronal cell line and is reportedly expressed in the mammalian brain. ...Thus, we propose th …
Role of Coactivator Associated Arginine Methyltransferase 1 (CARM1) in the Regulation of the Biological Function of 1,25-Dihydroxyvitamin D(3).
Mady LJ, Zhong Y, Dhawan P, Christakos S. Mady LJ, et al. Cells. 2023 May 17;12(10):1407. doi: 10.3390/cells12101407. Cells. 2023. PMID: 37408241 Free PMC article.
Treatment with TBBD, an inhibitor of CARM1, repressed 1,25(OH)(2)D(3) induced Cyp24a1 expression in MPCT cells, further suggesting that CARM1 is a significant coactivator of 1,25(OH)(2)D(3) induction of renal Cyp24a1 expression. CARM1 was found to act as a re …
Treatment with TBBD, an inhibitor of CARM1, repressed 1,25(OH)(2)D(3) induced Cyp24a1 expression in MPCT cells, further suggesting th …
Schistosoma mansoni coactivator associated arginine methyltransferase 1 (SmCARM1) effect on parasite reproduction.
Coelho FS, Gava SG, Andrade LF, Geraldo JA, Tavares NC, Lunkes FMN, Neves RH, Machado-Silva JR, Pierce RJ, Oliveira G, Mourão MM. Coelho FS, et al. Front Microbiol. 2023 Feb 24;14:1079855. doi: 10.3389/fmicb.2023.1079855. eCollection 2023. Front Microbiol. 2023. PMID: 36910171 Free PMC article.
Protein arginine methyltransferases (PRMTs) promote posttranslational modifications, modulating the function of histones and non-histone targets. The coactivator-associated arginine methyltransferase 1 (CARM1/PRMT4) is one of the S. manso …
Protein arginine methyltransferases (PRMTs) promote posttranslational modifications, modulating the function of histones and non-histone tar …
AMPK-dependent phosphorylation is required for transcriptional activation of TFEB and TFE3.
Paquette M, El-Houjeiri L, C Zirden L, Puustinen P, Blanchette P, Jeong H, Dejgaard K, Siegel PM, Pause A. Paquette M, et al. Autophagy. 2021 Dec;17(12):3957-3975. doi: 10.1080/15548627.2021.1898748. Epub 2021 Mar 18. Autophagy. 2021. PMID: 33734022 Free PMC article.
Altogether, we show that AMPK is a key regulator of TFEB and TFE3 transcriptional activity, and we validate AMPK as a promising target in cancer therapy to evade chemotherapeutic resistance.Abbreviations: ACACA: acetyl-CoA carboxylase alpha; ACTB: actin beta; AICAR: 5-aminoimidaz …
Altogether, we show that AMPK is a key regulator of TFEB and TFE3 transcriptional activity, and we validate AMPK as a promising target in ca …
Unraveling the complexity of histone-arginine methyltransferase CARM1 in cancer: From underlying mechanisms to targeted therapeutics.
Jin W, Zhang J, Chen X, Yin S, Yu H, Gao F, Yao D. Jin W, et al. Biochim Biophys Acta Rev Cancer. 2023 Jul;1878(4):188916. doi: 10.1016/j.bbcan.2023.188916. Epub 2023 May 15. Biochim Biophys Acta Rev Cancer. 2023. PMID: 37196782 Review.
Coactivator-associated arginine methyltransferase 1 (CARM1), a type I protein arginine methyltransferase (PRMT), has been widely reported to catalyze arginine methylation of histone and non-histone substrates, which is closely associated …
Coactivator-associated arginine methyltransferase 1 (CARM1), a type I protein arginine methyltrans …
Coactivator-Associated Arginine Methyltransferase-1 Function in Alveolar Epithelial Senescence and Elastase-Induced Emphysema Susceptibility.
Sarker RS, John-Schuster G, Bohla A, Mutze K, Burgstaller G, Bedford MT, Königshoff M, Eickelberg O, Yildirim AÖ. Sarker RS, et al. Am J Respir Cell Mol Biol. 2015 Dec;53(6):769-81. doi: 10.1165/rcmb.2014-0216OC. Am J Respir Cell Mol Biol. 2015. PMID: 25906418 Free PMC article.
A major feature of COPD is emphysema, which is the progressive loss of alveolar tissue. Coactivator-associated arginine methyltransferase-1 (CARM1) regulates histone methylation and the transcription of genes involved in senescence, proli …
A major feature of COPD is emphysema, which is the progressive loss of alveolar tissue. Coactivator-associated arginine …
368 results